The continued resistance of the indigenous population resulted in a series of further conflicts. On September 11, 1541 the Picunche chief Michimalonco led an attack on Santiago, beginning a three-year-long war. At the time, the Conquistadores were in a precarious situation, suffering persistent food shortages in almost complete isolation from the rest of the world.
In January of 1542, Pedro de Valdivia sent an emissary, Alonso de Monroy, to Peru to request help. The Conquistadors suffered 20 harsh months until de Monroy returned from Peru with reinforcements, ending the isolation and demoralizing situation of the soldiers in Santiago. The uprising ultimately failed and the indigenous population moved south.
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