Budget
Hostal Romandia Román Díaz 1403, Santiago, Chile. +5628913188 Located in a quiet residential district, the Hostal Romandia is a central Santiago de Chile bed and breakfast style accommodation perfect for business travelers, students, or guests who want to get a good night's sleep in order to discover the fascinating city of Santiago's attractions during their stay.
Footsteps Backpackers, Almirante Simpson 50, Santiago, Chile. checkin: 1:00 pm; checkout: 12:00 pm. A nice little hostel not too far from the trend area of Bellavista (Great nightlife). Close to the station Baquedano on the main red line of the metro. Breakfast and Wifi included. Good staff 6000 peso 8 dorm mixed.
Atacama Hostel Roman Diaz 130 +562264201 This great hostel has a great location close to bars, restaurants, clubs and both the bus and subway station. The newly remodeled rooms are cozy and colorful, the common room is huge, with lots of places to hang out and TV and DVDs, and the terrace is a great place for a bbq and views of the city! The water temperature in the showers here can be a bit temperamental, however.
Hostal Santa Lucia 168  Santa Lucia 168. Located at the best place you can expect, looking at the Santa Lucia hill and just blocks away of all the downtown happenings. A nice and need Hostel, great personal staf and good breakfast with fresh fruits!
Hostal del Barrio General Ekdhal 159, Barrio Bellavista: This hostel in a quiet area but nonetheless quite near to the hotspots of Barrio Bellavista. The rooms are not huge but very clean, including the bathroom. The German owner cares very well about his clients. 15000 CLP for a single with own bathroom. The breakfast is included and is rather big for Chilean hostels.
Hostal de la Barra  José Miguel de la Barra 451 (near to Museum Bellas Artes and Parque Forestal) +5626392384 This hostel is run directly in a old building in the middle of Neighborhood Bellas Artes, it has high quality infrastructure and also has a very nice coffee shop next door where the breakfast is served: The drawback is the 6 lane road outside which is rarely quiet and the early morning revellers returning home. Sleep is at a premium here. Good points are the staff, its situation and the nearby park areas.
casAltura Hostel, San Antonio 811 (near Parque Forestal, Santiago Centro), ? +56 2 6335076. Spacious hostel in a beautiful old building with a roof terrace. The interior is modern, comfortable, and always clean. It opened just a few months ago so it can be a little quiet at times, but if you're not looking for a party hostel you're sure to enjoy the laid back atmosphere. Very friendly and helpful staff. Free internet and WiFi. Dorms from Ch$10,800. 
Dominica Hostel Dominica 24, Bellavista +5627327196 This newly restored old house was especially design to receive travelers. Full of common spaces and with a practical design of the dorms rooms. Located few meters away from Cerro San Cristobal. Great place to stay in Santiago
Hostel Bellavista, Dardignac 0184, Barrio Bellavista, ? +56 2 7328737. Hostel located in a great area for dining out and nightlife but can be loud on the weekends. The staff is friendly with some glaring exceptions. There are several computers and free wifi from which you can access the Internet for free, and there's a large common room equipped with a TV, DVD player, plenty of seating, pool table and even a guitar. Very popular with young international backpackers and independent travelers. 
Hostal Providencia Vicuña Mackenna 92-A, Providencia +562 6352536 Rooms with private & shared bathrooms a house with an antique Chilean style with a modern twist. Staff is very helpful in giving the best tips to enjoy the city. Breakfast, BBQ, common areas with free internet and WiFi, cable TV and books and DVD library. Located only 3 min walking from Metro Baquedano, Plaza Italia walking distance to Bellavista neighborhood.
Hotel Angamos, Angamos 367, ? +56 2 2222849. Small hotel with clean and tidy rooms, double beds and hot water on demand. If there is none, you simply ask the owners to turn it on. They are a family run business who you can turn up to at any time of day/night and serve a simple breakfast in the price. It is pretty close to the centre and very safe. There is no hotel sign.. just ring the bell and be pleasantly surprised. 10000 per double room. 
La Chimba Hostel, Ernesto Pinto Lagarrigue 262, Barrio Bellavista, ? 735.8978. Small award-winning budget hostel in Santiago's trendiest barrio. Friendly staff and great facilities. Near metro station, La Chascona Cerro San Cristobal and the city's best bars and restaurants. $70. 
La Casa Roja, Av Agustinas 2113, ? +56 2 6964241. Hostel located in an old renovated mansion. The shared kitchen is huge and excellent. Its a party place, so it can get a bit noisy. Run-down area. Pool. Dorm rooms Ch$7000. One night free every six nights if paid beforehand.
Plaza de Armas Hostel, Compania 960, dpt 607 (South side of the Plaza de Armas, Santiago Centro), ? +56 2 6714436. checkin: 13:00; checkout: 11:00. Hostel located on the central square with a great view out over the plaza near the subway and museums. Small (located on an upper floor of a building) but lively place with good staff. You can access the Internet for free with three computers and wi-fi throughout the establishment, and there is a common room equipped with a two TVs and a DVD player. US$12-16 dormitory, US$34-38 double with shared bathroom, US$48-50 double with private bathroom. 
Residencia Tabita, Príncipe de gales 81 (off Moneda between San Martin and Amunategui), ? +56 2 6715700. Cosy, friendly and quiet, but right in the middle of town. 2000 pesos buys you unlimited internet access during your stay (Tabita's computer or WiFi). Singles from 8000 pesos, 15000 for doubles. 
Ventana Sur Hostel, Claudio Arrau 0340, Providencia (Close to Santa Isabel Metro station), ? +56 2 8950768. It's a chilled out hostel but there's always something going on. Good location handy for everything. Friendly staff: they always go the extra mile and they are great fun to hang out with. Pool, free internet and WiFi, great continental breakfast included, friday night BBQs, wednesday free wine nights and... duvets in the dorms! US$11-12 Dorms, US$21 Single with shared bathroom, US$36-44 Double with private bathroom. 
Pure Lounge, Ernesto Pino Lagarrigue 160, ? +56 2 732 22 73. A cozy hostel, very nicely decorated. Clean and quiet. A great place to make you feel at home while visiting Santiago. US$16 for a bed in a 8ppl dorm. 

Mid-range
Furchi E.I.R.L -Furnished Apartments-/ Bilbao3561, Av Francisco Bilbao & San Juan de Luz (in Providencia, one block from Bilbao metro station). Furnished two bedroom apartment, 58 square metres that sleeps up to four people. Includes full kitchen, washing machine, LCD TV , Cable, Desktop Computer with Internet, WiFi, DVD player, stereo, Chilean Cell Phone and free phone (local, national and international calls). The service also includes local access numbers in many cities around the world to call directly to the apartment as a local call. $70/night + $30 cleaning fee (USD).
Casa Bonita Bed&Breakfast, Pasaje Republica 5 (in Santiago Centro, 100 mts. from the Republica metro station). Established in a national monument in a protected historical neigbourhood, opened at the beginning of 2009. It offers single and double rooms with or without private bathroom and also has rooms for three or four persons. All rooms have central heating, cable TV and WIFI signal. Rates start from US$58 for a single and US$67 for a double. A varied breakfast, internet access and cable TV are included. This B&B is personally run by its owners, a Dutch-Chilean marriage.
Inmoba Apartments & Suites, Dr Ramon Corvalan 8 (corner Av Libertador, metro Baquedano or Universidad Catolica), ? 56-2-4195233. checkin: 2PM; checkout: 12PM. Serviced apartments on the top floors of this primarily residential tower block on Av. Libertador between Baquedano and Universidad Catolica metro stations. Excellent views over the city from the balcony and a daily cleaning service. The apartments have kitchens with microwave, oven and hob but no meals are provided, although there are many restaurants nearby to suit all budgets if you prefer not to cook for yourself. Internet access (ethernet cable provided, no wi-fi) is included in the price. There is a certain amount of noise inherent in the location, although no worse than in any other city centre. Good value for money and almost like having your own flat in the city. USD60/night single. 
NH Ciudad de Santiago, Avda. Condell, 40. Elegant hotel located in the centre of the city, a short distance from the primary metro line. The hotel contains 122 suites with private bathrooms, and separate bedroom and living room. Rooms contain sofa, minibar, television and wifi while the hotel itself offers a gym, sauna and swimming pool. 
Meridiano Sur, Petit Hotel, Santa Beatriz 256 Providencia, ? +56 2 2353659. checkin: 2PM; checkout: Noon. Five double rooms and two singles with private bathroom, satellite TV and wifi. There is also a loft with room for five. with a lot of partying Rooms $72-135, Loft $260 (rates cheaper May-Aug). 
MG Apartments, Pedro de Valdivia 263 (near Av 11 de Septiembre, metro Pedro de Valdivia), ? 56-2-83927177. Nice views over the city, towel changes must be asked. The apartments have complete kitchens with microwave, oven and hob but no meals or breakfast are provided, although there are many restaurants and cafes like starbucks nearby. Internet access (wi-fi) is included in the price. Furniture are modern and well conserved as the bed and pillows. There are cable TV and LCD monitors. Good cost-benefit and localization in the city. USD65/night double. 

Splurge
Grand Hyatt Santiago, Av Presidente Kennedy 4601, ? +56 2 950 1234. Has a 1000sq foot lagoon style pool, health club and several restaurants. 
Meridiano Sur, Petit Hotel, Santa Beatriz 256 Providencia, ? +56 2 2353659. checkin: 2PM; checkout: noon. Five double rooms and two singles with private bathroom, satellite TV and wifi. There is also a loft with room for five. $72-135, loft $260 (rates cheaper May-Aug). 
Hotel Fundador, Paseo Serrano 34, ? +56 2 3871200. Newly renovated hotel that is conveniently located for sightseeing in the historic centre of the city. It also has a good quality restaurant. Rooms $145-$185 and Suites $205-$260 (Apr, Oct - Nov); $30-$50 cheaper at other times. 
The Ritz-Carlton, Calle El Alcalde No. 15 (Las Condes district, near the El Golf metro station), ? +56 2 4708500. The hotel is, as expected, very nice. There are restaurants and bars nearby, a small park across the street and the neighborhood is modern and organized. 
Santiago Marriott Hotel, Av Presidente Kennedy 5741, ? +56 2 2462000. A popular business hotel in the city, the Santiago Marriott Hotel is in the Las Condes district, near excellent dining and shopping. Offers comfortable accommodations, a Lobby Bar, two first rated restaurants, meeting space and other modern amenities and services.